SHORT-COURSE THERAPY IN TUBERCULOUS MENINGITIS. A STUDY OF 16 PATIENTS

نویسندگان

  • ABBAS MONTAZERI
  • HOSSEIN PAHLAVANZADEH From the Department of Medicine, Section of Infectious arid Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
چکیده مقاله:

From 1986-1989, sixteen patients suffering from TB meningitis aged 12-58, with CSF smear or culture positive for Mycobacterium tuberculosis were hospitalized and treated with rifampin (RIF) , isoniazid (INH) , pyrazinamide (PZA) and ethambutol (ETB) for nine months. In all patients, ETB and PZA were withdrawn after three months and INH and RIF were continued for the next six months. 81.2 percent of patients were in stages 2 and 3 of this illness, and steroids were added to their treatment regimes. In two patients whose liver enzymes and blood uric acid levels increased during the second week of therapy, INH was discontinued temporarily and PZA was replaced with streptomycin. In the remaining patients, side effects of drugs and central, peripheral and other complications were trivial. Mortality rate was 25%, follow-up of the patients continued for 12-24 months. According to the mortality and morbidity of classic 12-18 months therapy with three drugs and results obtained in this study, treatment with four drugs for nine months showed some advantages to the other protocols. We look forward to finding more documents and similar studies from other centers. Confirmation of results of this study could be a suggestion for short-course therapy in TB meningitis, and this is the first report of short-course therapy in TB meningitis from Iran.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

short-course therapy in tuberculous meningitis. a study of 16 patients

from 1986-1989, sixteen patients suffering from tb meningitis aged 12-58, with csf smear or culture positive for mycobacterium tuberculosis were hospitalized and treated with rifampin (rif) , isoniazid (inh) , pyrazinamide (pza) and ethambutol (etb) for nine months. in all patients, etb and pza were withdrawn after three months and inh and rif were continued for the next six months. 81.2 percen...

متن کامل

A Five Years Study of Tuberculous Meningitis in Iran

Background: Tuberculous meningitis (TBM) is a severe form of extra pulmonary tuberculosis with high mortality and morbidity rate in all age group patients specific in adults and children. The incidence and prevalence are not exactly known in Iran. In this study, we tried to evaluate the role of rapid diagnosis and to find out the highest risk group patients.  Methods:Totally,...

متن کامل

a study of baudrillards ideas in brian moores fiction

پیدایش مرحله ی جدیدی از نظام سرمایه داری بعد از جنگ جهانی دوم همزمان است با ظهور عصر اطلاعات و رسانه جمعی. در چنین جامعه ای سیر آزادانه ی نشانه ها در فضای بی اساس مجازی بر سرعت فرسایش واقعیت می افزاید. به اعتقاد بودریار، فقدان واقعیت به واسطه ی شبیه سازی آن و تولید حاد واقعیت (hyperreality) پنهان خواهد ماند. این پژوهش بر آن است که جامعه فرانوین توصیف شده در سه رمان بریان مور را با توجه به نظر...

15 صفحه اول

a five years study of tuberculous meningitis in iran

background: tuberculous meningitis (tbm) is a severe form of extra pulmonary tuberculosis with high mortality and morbidity rate in all age group patients specific in adults and children. the incidence and prevalence are not exactly known in iran. in this study, we tried to evaluate the role of rapid diagnosis and to find out the highest risk group patients.  methods:totally, 1783-suspected pa...

متن کامل

Tuberculous meningitis (a clinico-pathological study).

Tuberculosis is a common infectious disease caused by Mycobacterium tuberculosis. One third of world's population is infected with tuberculosis, but only 10% of them will develop the clinical disease (1). Tuberculous Meningitis (TBM) was first described as a distinct pathological entity in 1836 (2). At present, TBM is the fifth most common extrapulmonary tuberculosis in the United States (US) a...

متن کامل

Six months therapy for tuberculous meningitis

BACKGROUND Tuberculous meningitis (TBM) is the main form of tuberculosis that affects the central nervous system and is associated with high rates of death and disability. Most international guidelines recommend longer antituberculous treatment (ATT) regimens for TBM than for pulmonary tuberculosis disease to prevent relapse. However, longer regimens are associated with poor adherence, which co...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 6  شماره 2

صفحات  89- 91

تاریخ انتشار 1992-08

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023